BIOGEN

Artículos científicos

• Pristine Photopolymerizable Gelatin Hydrogels: A Low-Cost and Easily Modifiable Platform for Biomedical Applications. Pérez-Araluce, M.; Cianciosi, A.; Iglesias-García, O.; Jüngst, T.; Sanmartín, C.; Navarro-Blasco, Í.; Prósper, F.; Plano, D.; Mazo, M.M. Pristine Photopolymerizable Gelatin Hydrogels: A Low-Cost and Easily Modifiable Platform for Biomedical Applications. Antioxidants 2024, 13, 1238.
• Generation of Self-Induced Myocardial Ischemia in Large-Sized Cardiac Spheroids without Alteration of Environmental Conditions Recreates Fibrotic Remodeling and Tissue Stiffening Revealed by Constriction Assays. Paz-Artigas L, González-Lana S, Polo N, Vicente P, Montero-Calle P, Martínez MA, Rábago G, Serra M, Prósper F, Mazo MM, González A, Ochoa I, Ciriza J. Generation of Self-Induced Myocardial Ischemia in Large-Sized Cardiac Spheroids without Alteration of Environmental Conditions Recreates Fibrotic Remodeling and Tissue Stiffening Revealed by Constriction Assays. ACS Biomater Sci Eng. 2024 Feb 12;10(2):987-997. Epub 2024 Jan 17. PMID: 38234159; PMCID: PMC10865285.
• Biomaterials-Based Antioxidant Strategies for the Treatment of Oxidative Stress Diseases . Perez-Araluce M, Jüngst T, Sanmartin C, Prosper F, Plano D, Mazo MM. Biomaterials-Based Antioxidant Strategies for the Treatment of Oxidative Stress Diseases. Biomimetics (Basel). 2024 Jan 3;9(1):23. PMID: 38248597; PMCID: PMC10813727. https://doi.org/10.3390/biomimetics9010023 
• Billion-Scale Expansion of Functional hiPSC-Derived Cardiomyocytes in Bioreactors Through Oxygen Control and Continuous Wnt Activation. Vicente P, Inocêncio LR, Ullate-Agote A, Louro AF, Jacinto J, Gamelas B, Iglesias-García O, Martin-Uriz PS, Aguirre-Ruiz P, Ríos-Muñoz GR, Fernández-Santos ME, van Mil A, Sluijter JPG, Prósper F, Vega MMM, Alves PM, Serra M. Billion-Scale Expansion of Functional hiPSC-Derived Cardiomyocytes in Bioreactors Through Oxygen Control and Continuous Wnt Activation. Adv Sci (Weinh). 2025 Mar;12(11):e2410510. Epub 2025 Jan 23. PMID: 39846380; PMCID: PMC11923921.
• 3D Human Myocardial Tissue Generation Using Melt Electrospinning Writing of Polycaprolactone Scaffolds and hiPSC-Derived Cardiac Cells. Sánchez-Bueno A, Iglesias-García O, Montero-Calle P, Gavira JJ, Prosper F, Mazo MM. 3D Human Myocardial Tissue Generation Using Melt Electrospinning Writing of Polycaprolactone Scaffolds and hiPSC-Derived Cardiac Cells. J Vis Exp. 2025 Mar 28;(217). PMID: 40227978.
• Biologically-Inspired Melt Electrowriting for the Generation of Highly Biomimetic Functional Myocardium. O. Iglesias-García, M. Flandes-Iparraguirre, P. Montero-Calle, R. M. Rosales, A. Ullate-Agote, A. Sánchez-Bueno, E. Larequi, I. Anaut-Lusar, N. Laita, A. Oliván-Viguera, E. Iglesias, G. Abizanda, P. San Martín-Úriz, P. Aguirre-Ruiz, X. L. Aranguren, M. García de Yébenes, J. J. Gavira, M. Á. Martínez, E. Peña, M. Doblaré, E. M. de-Juan-Pardo, E. Pueyo, F. Prosper, M. M. Mazo Vega, Biologically-Inspired Melt Electrowriting for the Generation of Highly Biomimetic Functional Myocardium. Adv. Funct. Mater. 2025, 2420106.

BIOGEN proiektuak organo kardiobaskularren fabrikazioari ekin dio laborategian, generoaren alderdian arreta jarriz. Horretarako, CAD diseinu konputazionaleko estrategiak, irudi medikoa, fabrikazio gehigarria eta giza zelula ama pluripotenteak bateratu ditugu. Teknologia horiekin, eta emakumeen eta gizonen irudiak eta zelulak erabiliz, aurrera egin dugu miokardioen, balbulen eta odol-hodien biofabrikazioan. hiPSC zelula ametatik abiatuta giza zelula kardiobaskularrak sortzeko prozesuak garatu ditugu, eta laborategian 3Dn inprimatzen ditugun egituretan dauden zelula-kopuru izugarriak sortzeko gai diren prozesuen garapenean aurrera egin dugu. Espero dugu datozen urteetan garapen horiek lagunduko dutela behar dituzten pazienteentzako terapia birsortzaileetarantz aurrera egiten.